UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.

Chen, Hongze; Li, Le; Hu, Jisheng; Zhao, Zhongjie; Ji, Liang; Cheng, Chundong; Zhang, Guangquan; Zhang, Tao; Li, Yilong; Chen, Hua; Pan, Shangha; Sun, Bei

Chen, Hongze; Li, Le; Hu, Jisheng; Zhao, Zhongjie; Ji, Liang; Cheng, Chundong; Zhang, Guangquan; Zhang, Tao; Li, Yilong; Chen, Hua; Pan, Shangha; Sun, Bei.

Afiliação

Chen H; Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, China.
Li L; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.
Hu J; Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, China.
Zhao Z; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.
Ji L; Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, China.
Cheng C; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.
Zhang G; Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, China.
Zhang T; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.
Li Y; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.
Chen H; Department of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Pan S; Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, China.
Sun B; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.

J Exp Clin Cancer Res ; 38(1): 297, 2019 Jul 09.

Article em En | MEDLINE | ID: mdl-31288830

Assuntos

Autofagia; Carcinoma Ductal Pancreático/metabolismo; Proteínas de Membrana Lisossomal/metabolismo; Neoplasias Pancreáticas/metabolismo; Ubiquitinas/metabolismo; Adulto; Idoso; Animais; Apoptose; Autofagia/genética; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/mortalidade; Carcinoma Ductal Pancreático/patologia; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células; Modelos Animais de Doenças; Feminino; Regulação Neoplásica da Expressão Gênica; Genes Reporter; Xenoenxertos; Humanos; Lisossomos/metabolismo; Masculino; Camundongos; Pessoa de Meia-Idade; Modelos Biológicos; Metástase Neoplásica; Estadiamento de Neoplasias; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/mortalidade; Neoplasias Pancreáticas/patologia; Prognóstico; Ligação Proteica; Ubiquitinas/genética; Neoplasias Pancreáticas

Palavras-chave

Autophagy; Lysosome associated membrane protein-1, LAMP1; Lysosome dysfunction; Pancreatic ductal adenocarcinoma, PDAC; Proliferation and metastasis; Ubiquitin-like protein 4A, UBL4A

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Autofagia / Ubiquitinas / Carcinoma Ductal Pancreático / Proteínas de Membrana Lisossomal Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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