Characterizing responsive and refractory orthotopic mouse models of hepatocellular carcinoma in cancer immunotherapy.

Hage, Carina; Hoves, Sabine; Ashoff, Mailin; Schandl, Veronika; Hört, Stefan; Rieder, Natascha; Heichinger, Christian; Berrera, Marco; Ries, Carola H; Kiessling, Fabian; Pöschinger, Thomas

Hage, Carina; Hoves, Sabine; Ashoff, Mailin; Schandl, Veronika; Hört, Stefan; Rieder, Natascha; Heichinger, Christian; Berrera, Marco; Ries, Carola H; Kiessling, Fabian; Pöschinger, Thomas.

Afiliação

Hage C; Roche Innovation Center Munich, Roche Pharmaceutical Research and Early Development, Penzberg, Germany.
Hoves S; Institute for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.
Ashoff M; Roche Innovation Center Munich, Roche Pharmaceutical Research and Early Development, Penzberg, Germany.
Schandl V; Roche Innovation Center Munich, Roche Pharmaceutical Research and Early Development, Penzberg, Germany.
Hört S; Roche Innovation Center Munich, Roche Pharmaceutical Research and Early Development, Penzberg, Germany.
Rieder N; Roche Innovation Center Munich, Roche Pharmaceutical Research and Early Development, Penzberg, Germany.
Heichinger C; Roche Innovation Center Munich, Roche Pharmaceutical Research and Early Development, Penzberg, Germany.
Berrera M; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Basel, Switzerland.
Ries CH; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Basel, Switzerland.
Kiessling F; Roche Innovation Center Munich, Roche Pharmaceutical Research and Early Development, Penzberg, Germany.
Pöschinger T; Institute for Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.

PLoS One ; 14(7): e0219517, 2019.

Article em En | MEDLINE | ID: mdl-31291357

Assuntos

Antineoplásicos Imunológicos/farmacologia; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Modelos Animais de Doenças; Neoplasias Hepáticas/tratamento farmacológico; Animais; Antígenos Transformantes de Poliomavirus/genética; Antineoplásicos Imunológicos/uso terapêutico; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Linfócitos T CD8-Positivos/imunologia; Antígeno CTLA-4/antagonistas & inibidores; Antígeno CTLA-4/imunologia; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/imunologia; Linhagem Celular Tumoral/transplante; Resistencia a Medicamentos Antineoplásicos; Ensaios de Seleção de Medicamentos Antitumorais/métodos; Feminino; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/imunologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Receptor de Morte Celular Programada 1/imunologia; Resultado do Tratamento; Microambiente Tumoral/efeitos dos fármacos; Microambiente Tumoral/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Carcinoma Hepatocelular / Modelos Animais de Doenças / Antineoplásicos Imunológicos / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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