Functional divergence caused by mutations in an energetic hotspot in ERK2.

Taylor, Clinton A; Cormier, Kevin W; Keenan, Shannon E; Earnest, Svetlana; Stippec, Steve; Wichaidit, Chonlarat; Juang, Yu-Chi; Wang, Junmei; Shvartsman, Stanislav Y; Goldsmith, Elizabeth J; Cobb, Melanie H

Taylor, Clinton A; Cormier, Kevin W; Keenan, Shannon E; Earnest, Svetlana; Stippec, Steve; Wichaidit, Chonlarat; Juang, Yu-Chi; Wang, Junmei; Shvartsman, Stanislav Y; Goldsmith, Elizabeth J; Cobb, Melanie H.

Afiliação

Taylor CA; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390.
Cormier KW; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390.
Keenan SE; Department of Chemical and Biological Engineering, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.
Earnest S; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390.
Stippec S; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390.
Wichaidit C; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390.
Juang YC; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390.
Wang J; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390.
Shvartsman SY; Department of Chemical and Biological Engineering, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.
Goldsmith EJ; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390.
Cobb MH; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390; melanie.cobb@utsouthwestern.edu.

Proc Natl Acad Sci U S A ; 116(31): 15514-15523, 2019 07 30.

Article em En | MEDLINE | ID: mdl-31296562

Assuntos

Proteínas de Drosophila/genética; Drosophila melanogaster/enzimologia; Drosophila melanogaster/genética; MAP Quinases Reguladas por Sinal Extracelular/genética; Mutação/genética; Animais; Animais Geneticamente Modificados; Cristalografia por Raios X; Proteínas de Drosophila/química; Proteínas de Drosophila/metabolismo; Ativação Enzimática; Estabilidade Enzimática; MAP Quinases Reguladas por Sinal Extracelular/química; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Humanos; Modelos Moleculares; Proteínas Mutantes/metabolismo

Palavras-chave

ERK CD site; kinase; mutation; stability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Drosophila / MAP Quinases Reguladas por Sinal Extracelular / Drosophila melanogaster / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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