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Triterpene saponins from the roots of Parkia bicolor A. Chev.
Bitchi, Michel Boni; Magid, Abdulmagid Alabdul; Yao-Kouassi, Philomène Akoua; Kabran, Faustin Aka; Harakat, Dominique; Martinez, Agathe; Morjani, Hamid; Tonzibo, Félix Zanahi; Voutquenne-Nazabadioko, Laurence.
Afiliação
  • Bitchi MB; Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France; Laboratoire de Chimie Organique Biologique, UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan 22, Cote d'Ivoire.
  • Magid AA; Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France.
  • Yao-Kouassi PA; Laboratoire de Chimie Organique Biologique, UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan 22, Cote d'Ivoire.
  • Kabran FA; Laboratoire de Chimie Organique Biologique, UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan 22, Cote d'Ivoire.
  • Harakat D; Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France.
  • Martinez A; Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France.
  • Morjani H; Université de Reims Champagne Ardenne, BioSpect EA 7506, 51097 Reims, France.
  • Tonzibo FZ; Laboratoire de Chimie Organique Biologique, UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan 22, Cote d'Ivoire. Electronic address: tonzibz@yahoo.fr.
  • Voutquenne-Nazabadioko L; Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France.
Fitoterapia ; 137: 104264, 2019 Sep.
Article em En | MEDLINE | ID: mdl-31299275
ABSTRACT
Five undescribed triterpene-type saponins, parkibicolorosides A-E, a cassane-type diterpene, and a known trimethoxy benzene glucoside were isolated from the roots of Parkia bicolor A. Chev. Their structures were elucidated by different spectroscopic methods including 1D- and 2D-NMR experiments as well as HR-ESI-MS analysis. Their cytotoxic activity against the chronic myeloid leukemia (K562) cell line was evaluated. The monosaccharides saponins exhibited a moderate antiproliferative activity with IC50 ranging from 48.49 ±â€¯0.16 to 81.66 ±â€¯0.17 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saponinas / Triterpenos / Raízes de Plantas / Fabaceae / Antineoplásicos Fitogênicos Limite: Humans País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saponinas / Triterpenos / Raízes de Plantas / Fabaceae / Antineoplásicos Fitogênicos Limite: Humans País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article