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Post-transplant malignancy in solid organ transplant recipients in Ireland, The Irish Transplant Cancer Group.
O'Neill, James Paul; Sexton, Donal J; O'Leary, Eamonn; O'Kelly, Patrick; Murray, Susan; Deady, Sandra; Daly, Fergus; Williams, Yvonne; Dean, Ben; Fitzgerald, Conall; Murad, Aizuri; Mansoor, Nazish; O'Neill, Jim O; Egan, Jim; Houlihan, Diarmaid D; McCormick, P Aiden; Morris, Patrick G; Ni Raghallaigh, Siona; Little, Dilly; Moloney, Fergal J; Conlon, Peter J.
Afiliação
  • O'Neill JP; Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital & The Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Sexton DJ; Royal College of Surgeons Ireland, Dublin, Ireland.
  • O'Leary E; Department of Transplant Urology and Nephrology, National Kidney Transplant Service, Beaumont Hospital Dublin, Dublin, Ireland.
  • O'Kelly P; National Cancer Registry Ireland, Cork, Ireland.
  • Murray S; Department of Transplant Urology and Nephrology, National Kidney Transplant Service, Beaumont Hospital Dublin, Dublin, Ireland.
  • Deady S; Department of Transplant Urology and Nephrology, National Kidney Transplant Service, Beaumont Hospital Dublin, Dublin, Ireland.
  • Daly F; National Cancer Registry Ireland, Cork, Ireland.
  • Williams Y; Department of Transplant Urology and Nephrology, National Kidney Transplant Service, Beaumont Hospital Dublin, Dublin, Ireland.
  • Dean B; Department of Transplant Urology and Nephrology, National Kidney Transplant Service, Beaumont Hospital Dublin, Dublin, Ireland.
  • Fitzgerald C; Department of Transplant Urology and Nephrology, National Kidney Transplant Service, Beaumont Hospital Dublin, Dublin, Ireland.
  • Murad A; Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital & The Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Mansoor N; Department of Dermatology, School of Medicine, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland.
  • O'Neill JO; Department of Dermatology, School of Medicine, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland.
  • Egan J; National Heart Transplant Center, Mater Misericordiae University Hospital, Dublin, Ireland.
  • Houlihan DD; National Lung Transplantation Center, Mater University Hospital Dublin, Dublin, Ireland.
  • McCormick PA; National Liver Transplant Center, St Vincent's University Hospital, Dublin, Ireland.
  • Morris PG; National Liver Transplant Center, St Vincent's University Hospital, Dublin, Ireland.
  • Ni Raghallaigh S; Royal College of Surgeons Ireland, Dublin, Ireland.
  • Little D; Department of Medical Oncology, Beaumont Hospital, Dublin, Ireland.
  • Moloney FJ; Department of Dermatology, Beaumont Hospital, Dublin, Ireland.
  • Conlon PJ; Department of Transplant Urology and Nephrology, National Kidney Transplant Service, Beaumont Hospital Dublin, Dublin, Ireland.
Clin Transplant ; 33(10): e13669, 2019 10.
Article em En | MEDLINE | ID: mdl-31310037
OBJECTIVE: Solid organ transplant recipients are at increased risk of cancer compared to the general population. To date, this risk in Ireland has not been investigated. We conducted a national registry study of cancer incidence following solid organ transplantation. METHODS: National centers for solid organ transplantation supplied their respective registry databases to cross-reference with episodes of malignancy from the National Cancer Registry Ireland (NCRI) between 1994 and 2014. Standardized incidence of cancer post-transplant was compared to the general population by means of standardized incidence ratios (SIRs), and between solid organ transplant types by incidence rate ratios. RESULTS: A total of 3346 solid organ transplant recipients were included in this study. Kidney transplant recipients constituted the majority of participants (71.2%), followed by liver (16.8%), heart (6.4%), and lung (5.6%) transplants. The most common cancers within the composite of all transplant recipients included the following (SIR [95% CI]): squamous and basal cell carcinoma (20.05 [17.97, 22.31] and 7.16 [6.43, 7.96], respectively), non-Hodgkin lymphoma (6.23 [4.26, 8.59]), and renal cell carcinoma (3.36 [1.96, 5.38]). CONCLUSIONS: This study reports the incidence of cancer following solid organ transplantation in Ireland. These results have significant national policy implications for surveillance, and early diagnosis in this patient group.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema de Registros / Transplante de Órgãos / Transplantados / Neoplasias Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema de Registros / Transplante de Órgãos / Transplantados / Neoplasias Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article