Patterns of sensitization to aeroallergens and their effect on airway hyper-responsiveness in Busan, Korea.
Asian Pac J Allergy Immunol
; 39(3): 182-189, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-31310146
ABSTRACT
BACKGROUND:
Allergen sensitization and its influence on allergic disease can vary depending on ethnicity and geography.OBJECTIVE:
To investigate aeroallergen sensitization patterns and their effect on airway hyper-responsiveness (AHR) in Busan, Korea.METHODS:
We reviewed data for subjects who attended for evaluation of respiratory symptoms between 2011 and 2016. The skin test results of 16 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, Alternaria, Aspergillus fumigatus, early blossoming tree pollen mix, late blossoming tree pollen mix, alder, birch, oak, grass mix, mugwort, ragweed, and Japanese hop) were analyzed. Age was categorized as group I (15 to < 65 years) or group II (≥ 65 years).RESULTS:
A total of 2,791 subjects were analyzed (mean age 50.9 years, female 61.3%). AHR was demonstrated in 15.8%; sputum eosinophilia in 12.1%; and atopy in 31.2%. The most commonly sensitizing allergen was house dust mite (17.4% to D. pteronyssinus and 17.9% to D. farinae), followed by late blossoming tree pollen mix (8.8%) and early blossoming tree pollen mix (8.6%). AHR was associated with sensitization to D. pteronyssinus, D. farina, Alternaria, dog, cat, alder, birch, oak, and mugwort. However, group II did not show any associations between AHR and any of the aeroallergens except D. farina. Multiple logistic regression analyses showed that the independent factors for AHR were ever-smoker status, D. farina, and oak sensitization.CONCLUSIONS:
Sensitization to house dust mites and tree pollen was found to be common in Busan. These aeroallergens significantly affected AHR, particularly in the younger group.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade Respiratória
/
Alérgenos
Limite:
Animals
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article