Mnemonic vulnerability induced by post-activation time-dependent new-learning.
Neurobiol Learn Mem
; 164: 107047, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31325495
ABSTRACT
Reactivation renders consolidated memory labile again, and the ensuing temporary reconsolidation process is highly susceptible to mnemonic modification. Here, we show that memories in such an unstable state could be influenced by sheer behavioral means, bypassing the need for pharmacological intervention. Across several experiments using a "face-location association" paradigm in which participants experienced a "Learning - New-learning - Final-test" procedure, we demonstrate that reactivated memory traces were hampered when the new learning was strategically administered at between 0-min and 20-min delay. Using fMRI, we further advance our theoretical understanding that this lability can be mechanistically explained by the differential activation in the hippocampal-amygdala memory system implicated by the post-activation new-learning whereas the mnemonic intrusion caused by newly learned memories is efficaciously reconciled by the left inferior frontal gyrus.
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Base de dados:
MEDLINE
Assunto principal:
Rememoração Mental
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Aprendizagem por Associação
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Consolidação da Memória
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Hipocampo
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Tonsila do Cerebelo
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article