Silica coated iron oxide nanoparticles-induced cytotoxicity, genotoxicity and its underlying mechanism in human HK-2 renal proximal tubule epithelial cells.

Královec, Karel; Havelek, Radim; Krocová, Eliska; Kucírková, Lucie; Hauschke, Martina; Bartácek, Jan; Palarcík, Jirí; Sedlák, Milos

Královec, Karel; Havelek, Radim; Krocová, Eliska; Kucírková, Lucie; Hauschke, Martina; Bartácek, Jan; Palarcík, Jirí; Sedlák, Milos.

Afiliação

Královec K; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic. Electronic address: karel.kralovec@upce.cz.
Havelek R; Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University, Simkova 870, Hradec Králové 500 03, Czech Republic.
Krocová E; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic.
Kucírková L; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic.
Hauschke M; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic.
Bartácek J; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
Palarcík J; Institute of Environmental and Chemical Engineering, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.
Sedlák M; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic.

Mutat Res Genet Toxicol Environ Mutagen ; 844: 35-45, 2019 Aug.

Article em En | MEDLINE | ID: mdl-31326033

Assuntos

Dano ao DNA; Células Epiteliais/efeitos dos fármacos; Óxido Ferroso-Férrico/toxicidade; Túbulos Renais Proximais/citologia; Nanopartículas de Magnetita/toxicidade; Dióxido de Silício/toxicidade; Apoptose/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Linhagem Celular; Transformação Celular Viral; Quebras de DNA de Cadeia Dupla; Genes p53; Histonas/genética; Humanos; Microtúbulos/efeitos dos fármacos; Testes de Mutagenicidade; Espécies Reativas de Oxigênio; Propriedades de Superfície

Palavras-chave

Cytotoxicity; DNA damage; Kidneys; Magnetic nanoparticles; ROS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Dióxido de Silício / Células Epiteliais / Óxido Ferroso-Férrico / Nanopartículas de Magnetita / Túbulos Renais Proximais Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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