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Discovery of a novel orally active TRPV4 inhibitor: Part 1. Optimization from an HTS hit.
Sami, Yuichi; Morita, Masataka; Kubota, Hirokazu; Hirabayashi, Ryoji; Seo, Ryushi; Nakagawa, Nobuaki.
Afiliação
  • Sami Y; Institute for Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: yuichi.sami@astellas.com.
  • Morita M; Institute for Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Kubota H; Institute for Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Hirabayashi R; Institute for Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Seo R; Institute for Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Nakagawa N; Institute for Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Bioorg Med Chem ; 27(17): 3775-3787, 2019 09 01.
Article em En | MEDLINE | ID: mdl-31327678
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Canais de Cátion TRPV / Descoberta de Drogas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Canais de Cátion TRPV / Descoberta de Drogas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article