In Vitro Synergy and In Vivo Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis.
Antimicrob Agents Chemother
; 63(10)2019 10.
Article
em En
| MEDLINE
| ID: mdl-31332060
ABSTRACT
The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vibrioses
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Ciprofloxacina
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Sepse
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Vibrio vulnificus
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Tigeciclina
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Antibacterianos
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article