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In Vitro Synergy and In Vivo Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis.
Kim, Seong Eun; Kim, Hee Kyung; Choi, Su-Mi; Yu, Yohan; Kim, Uh Jin; Darboe, Kalifa Sanneh; Kang, Seung-Ji; Park, Kyung-Hwa; Kang, Gaeun; Kim, Young Ran; Rhee, Joon Haeng; Jung, Sook-In; Jang, Hee-Chang.
Afiliação
  • Kim SE; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kim HK; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Choi SM; Department of Biomedical Science, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Yu Y; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kim UJ; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Darboe KS; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kang SJ; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Park KH; Department of Biomedical Science, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kang G; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kim YR; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Rhee JH; Department of Clinical Pharmacology, Chonnam National University Hospital, Gwangju, Republic of Korea.
  • Jung SI; College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea.
  • Jang HC; Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea.
Antimicrob Agents Chemother ; 63(10)2019 10.
Article em En | MEDLINE | ID: mdl-31332060
ABSTRACT
The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vibrioses / Ciprofloxacina / Sepse / Vibrio vulnificus / Tigeciclina / Antibacterianos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vibrioses / Ciprofloxacina / Sepse / Vibrio vulnificus / Tigeciclina / Antibacterianos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article