The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF-&#954;B pathway in non-small cell lung cancer cell lines A549 and NCI-H1299.

Guo, Weiqiang; Liu, Songbai; Ju, Xin; Du, Jiahui; Xu, Bin; Yuan, Hongxia; Qin, Fenju; Li, Liangzhi

The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF-κB pathway in non-small cell lung cancer cell lines A549 and NCI-H1299.

Guo, Weiqiang; Liu, Songbai; Ju, Xin; Du, Jiahui; Xu, Bin; Yuan, Hongxia; Qin, Fenju; Li, Liangzhi.

Afiliação

Guo W; School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, China.
Liu S; Suzhou Key Laboratory for Medical Biotechnology, Suzhou Vocational Health College, Suzhou, China.
Ju X; School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, China.
Du J; Suzhou Key Laboratory for Medical Biotechnology, Suzhou Vocational Health College, Suzhou, China.
Xu B; School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, China.
Yuan H; School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, China.
Qin F; School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, China.
Li L; School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, China.

J Cell Biochem ; 120(11): 18600-18607, 2019 11.

Article em En | MEDLINE | ID: mdl-31338882

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Apoptose/efeitos dos fármacos; Atractylodes/química; Proliferação de Células/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; NF-kappa B/metabolismo; Sesquiterpenos/farmacologia; Compostos de Espiro/farmacologia; Células A549; Proteínas Reguladoras de Apoptose/metabolismo; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Estrutura Molecular; Extratos Vegetais/farmacologia; Fase de Repouso do Ciclo Celular/efeitos dos fármacos; Sesquiterpenos/química; Compostos de Espiro/química; Fatores de Tempo

Palavras-chave

MEK/ERK; hinesol; lung cancer; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Compostos de Espiro / NF-kappa B / Apoptose / Sistema de Sinalização das MAP Quinases / Atractylodes / Proliferação de Células / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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