Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration.
Faraday Discuss
; 219(0): 244-251, 2019 10 30.
Article
em En
| MEDLINE
| ID: mdl-31339122
ABSTRACT
Glycosaminoglycan (GAG)-based biohybrid hydrogels of varied GAG content and GAG sulfation pattern were prepared and applied to sequester cytokines. The binding of strongly acidic and basic cytokines correlated with the integral space charge density of the hydrogel, while the binding of weakly charged cytokines was governed by the GAG sulfation pattern.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Hidrogéis
/
Glicosaminoglicanos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article