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Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112.
Bai, Meng; Huang, Guo-Lei; Mei, Rong-Qing; Wang, Bin; Luo, You-Ping; Nong, Xu-Hua; Chen, Guang-Ying; Zheng, Cai-Juan.
Afiliação
  • Bai M; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
  • Huang GL; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China.
  • Mei RQ; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
  • Wang B; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China.
  • Luo YP; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
  • Nong XH; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China.
  • Chen GY; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
  • Zheng CJ; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China.
Mar Drugs ; 17(8)2019 Jul 24.
Article em En | MEDLINE | ID: mdl-31344841
ABSTRACT
Three new lactones penicilactones A-C (1-3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo2(OAc)4-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 µg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC50 value of 78.5 (±0.58) µg/mL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penicillium / Inseticidas / Lactonas / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penicillium / Inseticidas / Lactonas / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article