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Mass Spectrometry in Advancement of Redox Precision Medicine.
Chen, Xiaofei; Lee, Jingyun; Wu, Hanzhi; Tsang, Allen W; Furdui, Cristina M.
Afiliação
  • Chen X; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Lee J; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Wu H; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA.
  • Tsang AW; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Furdui CM; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Adv Exp Med Biol ; 1140: 327-358, 2019.
Article em En | MEDLINE | ID: mdl-31347057
Redox (portmanteau of reduction-oxidation) reactions involve the transfer of electrons between chemical species in biological processes fundamental to life. It is of outmost importance that cells maintain a healthy redox state by balancing the action of oxidants and antioxidants; failure to do so leads to a multitude of diseases including cancer, diabetes, fibrosis, autoimmune diseases, and cardiovascular and neurodegenerative diseases. From the perspective of precision medicine, it is therefore beneficial to interrogate the redox phenotype of the individual-similar to the use of genomic sequencing-in order to design tailored strategies for disease prevention and treatment. This chapter provides an overview of redox metabolism and focuses on how mass spectrometry (MS) can be applied to advance our knowledge in redox biology and precision medicine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredução / Espectrometria de Massas / Estresse Oxidativo / Medicina de Precisão Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredução / Espectrometria de Massas / Estresse Oxidativo / Medicina de Precisão Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article