CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.

Chirackal Manavalan, Anil Paul; Pilarova, Kveta; Kluge, Michael; Bartholomeeusen, Koen; Rajecky, Michal; Oppelt, Jan; Khirsariya, Prashant; Paruch, Kamil; Krejci, Lumir; Friedel, Caroline C; Blazek, Dalibor

Chirackal Manavalan, Anil Paul; Pilarova, Kveta; Kluge, Michael; Bartholomeeusen, Koen; Rajecky, Michal; Oppelt, Jan; Khirsariya, Prashant; Paruch, Kamil; Krejci, Lumir; Friedel, Caroline C; Blazek, Dalibor.

Afiliação

Chirackal Manavalan AP; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Pilarova K; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Kluge M; Institut für Informatik, Ludwig-Maximilians-Universität München, München, Germany.
Bartholomeeusen K; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Rajecky M; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Oppelt J; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Khirsariya P; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Brno, Czech Republic.
Paruch K; Center of Biomolecular and Cellular Engineering, International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.
Krejci L; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Brno, Czech Republic.
Friedel CC; Center of Biomolecular and Cellular Engineering, International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.
Blazek D; Center of Biomolecular and Cellular Engineering, International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.

EMBO Rep ; 20(9): e47592, 2019 09.

Article em En | MEDLINE | ID: mdl-31347271

Assuntos

Quinases Ciclina-Dependentes/metabolismo; Quinases Ciclina-Dependentes/genética; Reparo do DNA/genética; Reparo do DNA/fisiologia; Replicação do DNA/genética; Replicação do DNA/fisiologia; Pontos de Checagem da Fase G1 do Ciclo Celular/genética; Pontos de Checagem da Fase G1 do Ciclo Celular/fisiologia; Células HCT116; Humanos; Fosforilação; RNA Polimerase II/genética; RNA Polimerase II/metabolismo

Palavras-chave

CDK12; CTD Ser2 phosphorylation; G1/S; premature termination and polyadenylation; tandem duplications

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases Ciclina-Dependentes Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases Ciclina-Dependentes Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article