Clinical and laboratory outcomes following total or partial splenectomy in patients with hereditary spherocytosis.
Pediatr Hematol Oncol
; 36(6): 382-389, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31347415
ABSTRACT
This study compared outcomes following total (TS) or partial splenectomy (PS) among patients with hereditary spherocytosis. Seventy-nine patients (TS = 33, PS = 46) were identified. The follow-up period was longer after PS (59.6 vs. 24.9 months, p < .001). Long-term adverse events occurred more frequently following PS (50% vs. 29%, p = .001). Anemia, jaundice, and fatigue recurred in six patients with PS, leading to five completion splenectomies. Hemoglobin was not different between PS and TS by 5 years post-procedure (12.3 vs. 13.4 g/dL, p = .25). Both PS and TS ameliorate symptoms and improve hematologic parameters. The rate of secondary surgery following PS should be considered when planning the initial surgical procedure.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esferocitose Hereditária
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Esplenectomia
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Laboratórios
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article