Longitudinal follow-up of biopsy-proven small fiber neuropathy.
Muscle Nerve
; 60(4): 376-381, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31348533
ABSTRACT
INTRODUCTION:
Little is published on the prognosis of small fiber neuropathy (SFN).METHODS:
A retrospective analysis of 101 patients with biopsy proven SFN.RESULTS:
Study participants included 87 patients with length-dependent SFN and 14 patients with non-length-dependent SFN. The average duration of symptoms was 3.2 years prior to SFN diagnosis, and the average follow-up duration after diagnosis was 6.2 years. Neuropathic pain was present in 98% of patients and in 84.2% of patients at the final visit. The average total number of pain medications ever used was 4.4 per patient. Signs of autonomic dysfunction were initially present in 24.8% of patients, but improved in most. Large fiber involvement was seen in 11.9% of patients. Small fiber neuropathy affected employment and ambulation status in 5.3% and 6.3% of patients, respectively.DISCUSSION:
Small fiber neuropathy tends to be stable and rarely affects ambulation and employment status. Effective pain control remains a challenge.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Autônomo
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Emprego
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Limitação da Mobilidade
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Neuropatia de Pequenas Fibras
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Neuralgia
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article