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Design of polymer-based antimicrobial hydrogels through physico-chemical transition.
Mauri, Emanuele; Naso, Davide; Rossetti, Arianna; Borghi, Elisa; Ottaviano, Emerenziana; Griffini, Gianmarco; Masi, Maurizio; Sacchetti, Alessandro; Rossi, Filippo.
Afiliação
  • Mauri E; Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy.
  • Naso D; Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy.
  • Rossetti A; Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy.
  • Borghi E; Department of Health Sciences, Università degli Studi di Milano, via Di Rudinì 8, 20142 Milan, Italy.
  • Ottaviano E; Department of Health Sciences, Università degli Studi di Milano, via Di Rudinì 8, 20142 Milan, Italy.
  • Griffini G; Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy.
  • Masi M; Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy.
  • Sacchetti A; Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy. Electronic address: alessandro.sacchetti@polimi.it.
  • Rossi F; Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy. Electronic address: filippo.rossi@polimi.it.
Mater Sci Eng C Mater Biol Appl ; 103: 109791, 2019 Oct.
Article em En | MEDLINE | ID: mdl-31349504
ABSTRACT
The antimicrobial activity represents a cornerstone in the development of biomaterials it is a leading request in many areas, including biology, medicine, environment and industry. Over the years, different polymeric scaffolds are proposed as solutions, based on the encapsulation of metal ions/particles, antibacterial agents or antibiotics. However, the compliance with the biocompatibility criteria and the concentration of the active principles to avoid under- and over-dosing are being debated. In this work, we propose the synthesis of a versatile hydrogel using branched polyacrylic acid (carbomer 974P) and aliphatic polyetherdiamine (elastamine®) through physico-chemical transition, able to show its ability to counteract the bacterial growth and infections thanks to the polymers used, that are not subjected to further chemical modifications. In particular, the antimicrobial activity is clearly demonstrated against Staphyloccoccus aureus and Candida albicans, two well-known opportunistic pathogens. Moreover, we discuss the hydrogel use as drug carrier to design a unique device able to combine the antibacterial/antimicrobial properties to the controlled drug delivery, as a promising tool for a wide range of biomedical applications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Hidrogéis / Anti-Infecciosos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Hidrogéis / Anti-Infecciosos Idioma: En Ano de publicação: 2019 Tipo de documento: Article