Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.

Xu, Man; Peng, Yongzhi; Zhu, Li; Wang, Shulin; Ji, Jiayou; Rakesh, K P

Xu, Man; Peng, Yongzhi; Zhu, Li; Wang, Shulin; Ji, Jiayou; Rakesh, K P.

Afiliação

Xu M; School of Materials Science and Engineering, Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province, Wuhan Institute of Technology, Wuhan, 430205, PR China.
Peng Y; School of Materials Science and Engineering, Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province, Wuhan Institute of Technology, Wuhan, 430205, PR China.
Zhu L; School of Materials Science and Engineering, Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province, Wuhan Institute of Technology, Wuhan, 430205, PR China.
Wang S; School of Materials Science and Engineering, Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province, Wuhan Institute of Technology, Wuhan, 430205, PR China.
Ji J; School of Materials Science and Engineering, Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province, Wuhan Institute of Technology, Wuhan, 430205, PR China.
Rakesh KP; School of Materials Science and Engineering, Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province, Wuhan Institute of Technology, Wuhan, 430205, PR China. Electronic address: rakeshasg@gmail.com.

Eur J Med Chem ; 180: 656-672, 2019 Oct 15.

Article em En | MEDLINE | ID: mdl-31352246

Assuntos

Doença de Alzheimer/tratamento farmacológico; Inibidores da Colinesterase/farmacologia; Fármacos Neuroprotetores/farmacologia; Triazóis/farmacologia; Acetilcolinesterase/metabolismo; Doença de Alzheimer/metabolismo; Butirilcolinesterase/metabolismo; Inibidores da Colinesterase/química; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Fármacos Neuroprotetores/química; Relação Estrutura-Atividade; Triazóis/química

Palavras-chave

Alzheimer's disease; SAR studies; Triazoles

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Inibidores da Colinesterase / Fármacos Neuroprotetores / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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