Factors Predictive of Subretinal Fluid Resolution in Coats Disease: Analysis of 177 Eyes in 177 Patients at a Single Center.
Asia Pac J Ophthalmol (Phila)
; 8(4): 290-297, 2019.
Article
em En
| MEDLINE
| ID: mdl-31356365
ABSTRACT
PURPOSE:
The aim of this study was to investigate factors predictive of subretinal fluid (SRF) resolution in Coats disease.DESIGN:
Retrospective cohort study.METHODS:
Institutional review board-approved review of patients diagnosed with Coats disease demonstrating SRF (stage 3-5) at a single center from November 1973 to July 2018 with comparison of eyes that had resolution of SRF to those in which SRF persisted.RESULTS:
There were 177 cases (154 males, 87%) of Coats disease diagnosed at a mean age of 8 years. After a mean follow-up of 62 months, SRF resolved in 110 (62%) and persisted in 67 (38%) eyes. Comparison (resolved SRF vs persistent SRF) revealed classification as stage 3A [63 (57%) vs 20 (29%)], stage 3B [47 (43%) vs 40 (60%)], or stage 4 [0 (0%) vs 7 (11%)] (Pâ<â0.001). Eyes with resolved SRF presented with fewer clock hours of telangiectasia (mean 5 vs 7 clock hours, Pâ<â0.001), light bulb aneurysms (mean 5 vs 7 clock hours, Pâ<â0.001), exudation (mean 7 vs 10 clock hours, Pâ<â0.001), and extent of SRF (mean 7 vs 10 clock hours, Pâ<â0.001). Factors predictive of SRF resolution included absence of iris neovascularization on fluorescein angiography [odds ratio 0.05 (95% confidence interval 0.01-0.60), Pâ=â0.02], and less elevated SRF by ultrasonography [odds ratio 0.84 (95% confidence interval 0.76-0.95), Pâ=â0.004). For every 1-mm decrease in SRF, likelihood of SRF resolution increased by 16%.CONCLUSIONS:
Resolution of SRF was achieved in the majority of eyes (62%) with stage 3 to 5 Coats disease. Predictors of SRF resolution included lack of neovascularization on fluorescein angiography and less elevation of SRF by ultrasonography.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retina
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Angiofluoresceinografia
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Acuidade Visual
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Tomografia de Coerência Óptica
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Líquido Sub-Retiniano
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Telangiectasia Retiniana
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
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Newborn
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article