Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors.
Biomolecules
; 9(8)2019 07 27.
Article
em En
| MEDLINE
| ID: mdl-31357634
ABSTRACT
Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are mostly localized at the plasma membrane in lipid raft domains and implicated in many cellular signaling pathways mostly by interacting with tyrosine kinase receptors. Gangliosides are divided into four series according to the number of sialic acid residues, which can be also modified by O-acetylation. Both ganglioside expression and sialic acid modifications can be modified in pathological conditions such as cancer, which can induce either pro-cancerous or anti-cancerous effects. In this review, we summarize the specific functions of gangliosides in neuro-ectodermal derived tumors, and their roles in reprogramming the lipidomic profile of cell membrane occurring with the induction of epithelial-mesenchymal transition.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tumores Neuroectodérmicos
/
Gangliosídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article