Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors.
Arch Pharm (Weinheim)
; 352(9): e1900107, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31359502
ABSTRACT
Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR-PI376, as highly potent agonists at the human histamine H4 receptor (hH4 R). While imidazole-containing compounds display drawbacks in pharmacokinetics, we studied the possibility of replacing the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Beyond that, this approach should give more information about the indispensability of the aromatic ring as a basic head group. Besides these changes, a variation of the spacer length (C3 -C5 ) connecting the heterocycle and the cyanoguanidine moiety has been made to possibly trigger the selectivity towards the respective HRs. Investigations in radioligand-binding assays exhibited only very weak activity at the hH1 R and hH3 R, while nearly all compounds were inactive at the hH2 R and hH4 R. In the case of piperidine-containing compounds, moderate affinities at the hH3 R over the single-digit micromolar range were detected.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Histamínicos
/
Agonistas dos Receptores Histamínicos
/
Guanidinas
/
Compostos Heterocíclicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article