Inhibition of ß-amyloid-induced neurotoxicity by planar analogues of procyanidin B3.
Bioorg Med Chem Lett
; 29(18): 2659-2663, 2019 09 15.
Article
em En
| MEDLINE
| ID: mdl-31371134
ABSTRACT
Reactive oxygen species (ROS) are known to be produced during the amyloid beta (Aß) aggregation process. Both ROS production and Aß fibril formation can result in nerve cell injury. Proanthocyanidins are oligomers of catechin that can act as inhibitors of Aß aggregation. Procyanidin B3 (Cat-Cat), the dimer of (+)-catechin, can easily cross the blood-brain barrier. Previously, we synthesized two derivatives of Cat-Cat, namely Cat-PCat and PCat-PCat, in which the geometry of one or both catechin molecules in Cat-Cat was constrained to be planar. The antioxidative activities of Cat-PCat and PCat-PCat were found to be stronger than that of Cat-Cat, with PCat-PC at exhibiting the most potent activity. These compounds are predicted to protect against Aß-induced neurotoxicity via inhibition of Aß aggregation as well as by antioxidative effects toward Aß-induced intracellular ROS generation. PCat-PCat exhibited the most potent neuroprotective effects against Aß-induced cytotoxicity, which resulted from inhibition of ß-sheet structure formation during the Aß aggregation process. PCat-PCat may be a promising lead compound for the treatment of Alzheimer's disease.
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Base de dados:
MEDLINE
Assunto principal:
Catequina
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Peptídeos beta-Amiloides
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Fármacos Neuroprotetores
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Biflavonoides
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Proantocianidinas
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Antioxidantes
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article