How liquid biopsies can change clinical practice in oncology.
Ann Oncol
; 30(10): 1580-1590, 2019 10 01.
Article
em En
| MEDLINE
| ID: mdl-31373349
ABSTRACT
Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a variety of clinical applications. ctDNA is being used to genotype solid cancers non-invasively, to track tumor dynamics and to detect the emergence of drug resistance. In a few settings, liquid biopsies have already entered clinical practice. For example, ctDNA is used to guide treatment in a subset of lung cancers. In this review, we discuss how recent improvements in the sensitivity and accuracy of ctDNA analyses have led to unprecedented advances in this research field. We further consider what is required for the routine deployment of liquid biopsies in the clinical diagnostic space. We pinpoint technical hurdles that liquid biopsies have yet to overcome, including preanalytical and analytical challenges. We foresee how liquid biopsies will transform clinical practice by complementing (or replacing) imaging to monitor treatment response and by detecting minimal residual disease after surgery with curative intent.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Padrões de Prática Médica
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DNA de Neoplasias
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Biomarcadores Tumorais
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Tomada de Decisão Clínica
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DNA Tumoral Circulante
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Biópsia Líquida
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Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article