The molecular mechanisms mediating mammalian fertilization.
Development
; 146(15)2019 08 02.
Article
em En
| MEDLINE
| ID: mdl-31375552
ABSTRACT
Fertilization is a key biological process in which the egg and sperm must recognize one another and fuse to form a zygote. Although the process is a continuum, mammalian fertilization has been studied as a sequence of steps:
sperm bind and penetrate through the zona pellucida of the egg, adhere to the egg plasma membrane and finally fuse with the egg. Following fusion, effective blocks to polyspermy ensure monospermic fertilization. Here, we review how recent advances obtained using genetically modified mouse lines bring new insights into the molecular mechanisms regulating mammalian fertilization. We discuss models for these processes and we include studies showing that these mechanisms may be conserved across different mammalian species.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interações Espermatozoide-Óvulo
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Espermatozoides
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Zona Pelúcida
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Fertilização
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article