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Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population.
Asadzadeh, Azizeh; Seyedhosseini Ghaheh, Hooria; Sholehvar, Fatemeh; Takhshid, Mohammadali; Naghizadeh, Mohammad Mehdi.
Afiliação
  • Asadzadeh A; Department of Biology, University of Nourdanesh Institute of Higher Education, Meymeh, Isfahan, Iran.
  • Seyedhosseini Ghaheh H; Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • Sholehvar F; Department of Biology, Faculty of Science, Zand Institute of Higher Education, Shiraz, Iran.
  • Takhshid M; Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Naghizadeh MM; Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Avicenna J Med Biotechnol ; 11(3): 239-244, 2019.
Article em En | MEDLINE | ID: mdl-31379997
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a serious problem in the world. 5-Hydroxytryptamine (5-HT, serotonin) plays an important role in obesity, glucose control and insulin resistance. The polymorphism of the serotonin transporter gene linked promoter region (5-HTTLPR) might influence 5-HTT expression and serotonin uptake. The polymorphism results in two alleles of L (Long) and S (Short). The aim of the present study was to evaluate the association between 5-HTTLPR genotypes in type 2 diabetes mellitus (T2DM), obesity as well as serum biochemical profiles in Iranian population from 2012 until 2015. METHODS: 180 patients with T2DM and 180 controls were selected and the frequency of S and L alleles was determined by PCR. Then, the relationship between genotypes, body mass index (BMI) and serum biochemical variables was investigated. RESULTS: The frequency of S and L alleles in experimental and control groups was the same [for the L allele p=0.754, OR (95%CI)=1.103 (0.597 to 2.041) and for the S allele p=0.906, OR (95%CI)=(0.490 to 1.676)]. However, the mean triglyceride, cholesterol, LDL-C, systolic and diastolic blood pressure levels in the diabetic subjects with LL genotype were significantly higher than LS and SS genotypes (p<0.001) in this population. CONCLUSION: The L allele of 5-HTTLPR was related to the increased serum lipids and blood pressure in the diabetic patients. However, there was no relationship between the polymorphism of 5-HTTLPR L/S and T2DM in Iranian population.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article