Synthesis, Characterization and Antimicrobial Activity of Garcinol Capped Silver Nanoparticles.
J Microbiol Biotechnol
; 29(11): 1841-1851, 2019 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-31387343
ABSTRACT
Garcinol, a well-known medicinal phytochemical, was extracted and isolated from the dried fruit rinds of Garcinia quaesita Pierre. In this study, garcinol has successfully used to reduce silver ions to silver in order to synthesize garcinol-capped silver nanoparticles (G-AgNPs). The formation and the structure of G-AgNPs were confirmed by UV-visible spectroscopy, transmission electron microscopy and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of garcinol and G-AgNPs were investigated by well diffusion assays, broth micro-dilution assays and time-kill kinetics studies against five microbial species, including Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and clinically isolated methicillin-resistant Staphylococcus aureus (MRSA). The formation of G-AgNPs is a promising novel approach to enhancing the biological activeness of silver nanoparticles, and to increase the water solubility of garcinol which creates a broad range of therapeutic applications.
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Base de dados:
MEDLINE
Assunto principal:
Prata
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Terpenos
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Nanopartículas Metálicas
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Anti-Infecciosos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article