End of season influenza vaccine effectiveness in adults and children in the United Kingdom in 2017/18.
Euro Surveill
; 24(31)2019 Aug.
Article
em En
| MEDLINE
| ID: mdl-31387673
ABSTRACT
BackgroundIn the United Kingdom (UK), in recent influenza seasons, children are offered a quadrivalent live attenuated influenza vaccine (LAIV4), and eligible adults mainly trivalent inactivated vaccine (TIV).AimTo estimate the UK end-of-season 2017/18 adjusted vaccine effectiveness (aVE) and the seroprevalence in England of antibodies against influenza viruses cultured in eggs or tissue.MethodsThis observational study employed the test-negative case-control approach to estimate aVE in primary care. The population-based seroprevalence survey used residual age-stratified samples.ResultsInfluenza viruses A(H3N2) (particularly subgroup 3C.2a2) and B (mainly B/Yamagata/16/88-lineage, similar to the quadrivalent vaccine B-virus component but mismatched to TIV) dominated. All-age aVE was 15% (95% confidence interval (CI) -6.3 to 32) against all influenza; -16.4% (95% CI -59.3 to 14.9) against A(H3N2); 24.7% (95% CI 1.1 to 42.7) against B and 66.3% (95% CI 33.4 to 82.9) against A(H1N1)pdm09. For 2-17 year olds, LAIV4 aVE was 26.9% (95% CI -32.6 to 59.7) against all influenza; -75.5% (95% CI -289.6 to 21) against A(H3N2); 60.8% (95% CI 8.2 to 83.3) against B and 90.3% (95% CI 16.4 to 98.9) against A(H1N1)pdm09. For ≥ 18 year olds, TIV aVE against influenza B was 1.9% (95% CI -63.6 to 41.2). The 2017 seroprevalence of antibody recognising tissue-grown A(H3N2) virus was significantly lower than that recognising egg-grown virus in all groups except 15-24 year olds.ConclusionsOverall aVE was low driven by no effectiveness against A(H3N2) possibly related to vaccine virus egg-adaption and a new A(H3N2) subgroup emergence. The TIV was not effective against influenza B. LAIV4 against influenza B and A(H1N1)pdm09 was effective.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza B
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Vacinas Atenuadas
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Vacinas de Produtos Inativados
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Surtos de Doenças
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Influenza Humana
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Vírus da Influenza A Subtipo H1N1
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Vírus da Influenza A Subtipo H3N2
Tipo de estudo:
Observational_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article