Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15.

Guo, Yuna; Ayers, Jessica L; Carter, Kelly T; Wang, Ting; Maden, Sean K; Edmond, Darwin; Newcomb P, Polly; Li, Christopher; Ulrich, Cornelia; Yu, Ming; Grady, William M

Guo, Yuna; Ayers, Jessica L; Carter, Kelly T; Wang, Ting; Maden, Sean K; Edmond, Darwin; Newcomb P, Polly; Li, Christopher; Ulrich, Cornelia; Yu, Ming; Grady, William M.

Afiliação

Guo Y; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Ayers JL; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Carter KT; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Wang T; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Maden SK; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Edmond D; University of Washington, Seattle, Washington.
Newcomb P P; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Li C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Ulrich C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Yu M; Department of Population Health Sciences, Huntsman Cancer Institute, Salt Lake City, Utah.
Grady WM; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Aging Cell ; 18(6): e13013, 2019 12.

Article em En | MEDLINE | ID: mdl-31389184

Assuntos

Envelhecimento; Senescência Celular; Neoplasias do Colo/metabolismo; Fator 15 de Diferenciação de Crescimento/metabolismo; Microambiente Tumoral; Envelhecimento/genética; Células Cultivadas; Senescência Celular/genética; Neoplasias do Colo/patologia; Fibroblastos/metabolismo; Fator 15 de Diferenciação de Crescimento/genética; Fator 15 de Diferenciação de Crescimento/isolamento & purificação; Células HEK293; Humanos; Fenótipo; RNA Mensageiro/genética; RNA Mensageiro/isolamento & purificação; RNA Mensageiro/metabolismo; Microambiente Tumoral/genética

Palavras-chave

GDF15; colon organoids; colorectal cancer; microenvironment; senescence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Senescência Celular / Neoplasias do Colo / Fator 15 de Diferenciação de Crescimento / Microambiente Tumoral Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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