A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method.

Carter, Simon J; Ferecskó, Alex S; King, Lloyd; Ménochet, Karelle; Parton, Ted; Chappell, Michael J

Carter, Simon J; Ferecskó, Alex S; King, Lloyd; Ménochet, Karelle; Parton, Ted; Chappell, Michael J.

Afiliação

Carter SJ; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, United Kingdom.
Ferecskó AS; UCB Pharma Ltd, Slough, United Kingdom.
King L; UCB Pharma Ltd, Slough, United Kingdom.
Ménochet K; UCB Pharma Ltd, Slough, United Kingdom.
Parton T; Mekinopsis Ltd, London, United Kingdom.
Chappell MJ; Biomedical and Biological Systems Laboratory, School of Engineering, University of Warwick, Coventry, United Kingdom.

Xenobiotica ; 50(4): 415-426, 2020 Apr.

Article em En | MEDLINE | ID: mdl-31389297

Assuntos

Atorvastatina/metabolismo; Ciclosporina/metabolismo; Fígado/metabolismo; Animais; Transporte Biológico; Hepatócitos; Modelos Químicos; Ratos

Palavras-chave

Mechanistic modelling; atorvastatin; competitive inhibition; cyclosporine; high throughput; inhibition mechanism; metabolism; micro-rate constant; non-competitive inhibition; rat hepatocyte uptake

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciclosporina / Atorvastatina / Fígado Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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