Intermolecular 1,4-Carboamination of Conjugated Dienes Enabled by Cp*RhIII -Catalyzed C-H Activation.
Angew Chem Int Ed Engl
; 58(42): 15041-15045, 2019 10 14.
Article
em En
| MEDLINE
| ID: mdl-31389654
ABSTRACT
A protocol for the three-component 1,4-carboamination of dienes is described. Synthetically versatile Weinreb amides were coupled with 1,3-dienes and readily available dioxazolones as the nitrogen source using [Cp*RhCl2 ]2 -catalyzed C-H activation to deliver the 1,4-carboaminated products. This transformation proceeds under mild reaction conditions and affords the products with high levels of regio- and E-selectivity. Mechanistic investigations suggest an intermediate RhIII -allyl species is trapped by an electrophilic amidation reagent in a redox-neutral fashion.
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MEDLINE
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En
Ano de publicação:
2019
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Article