Direct thiocarbamation of imidazoheterocycles via dual C-H sulfurization.
Org Biomol Chem
; 17(34): 7854-7857, 2019 08 28.
Article
em En
| MEDLINE
| ID: mdl-31408075
ABSTRACT
A copper-catalyzed DTBP oxidative dual C-H sulfurization has been developed for the direct thiocarbamation of imidazopyridines using a combination of elemental sulfur and formamides as carbamothioyl surrogates. NBS (bromo succinimide) was found to promote the thiocarbamation in good yields. This dual C-H sulfurization strategy enables access to a wide range of carbamothioyl imidazoheterocycles without the use of highly toxic phosgene.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
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Article