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Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
Wang, Heming; Lane, Jacqueline M; Jones, Samuel E; Dashti, Hassan S; Ollila, Hanna M; Wood, Andrew R; van Hees, Vincent T; Brumpton, Ben; Winsvold, Bendik S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G; Bechtold, David A; Bowden, Jack; Emsley, Richard; Kyle, Simon D; Little, Max A; Loudon, Andrew S; Scheer, Frank A J L; Purcell, Shaun M; Richmond, Rebecca C; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B; Willer, Cristen J; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M; Ray, David; Lawlor, Deborah A; Rutter, Martin K; Weedon, Michael N; Redline, Susan; Saxena, Richa.
Afiliação
  • Wang H; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Lane JM; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Jones SE; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Dashti HS; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Ollila HM; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Wood AR; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
  • van Hees VT; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Brumpton B; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Winsvold BS; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Kantojärvi K; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Palviainen T; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Cade BE; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
  • Sofer T; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Song Y; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
  • Patel K; Netherlands eScience Center, Amsterdam, Netherlands.
  • Anderson SG; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
  • Bechtold DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
  • Bowden J; Department of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Emsley R; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
  • Kyle SD; Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Little MA; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.
  • Loudon AS; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
  • Scheer FAJL; Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
  • Purcell SM; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Richmond RC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Spiegelhalder K; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Tyrrell J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Zhu X; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Hublin C; Northeastern University College of Science, Boston, MA, USA.
  • Kaprio JA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Kristiansson K; Northeastern University College of Science, Boston, MA, USA.
  • Sulkava S; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
  • Paunio T; The George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, University of the West Indies, Cave Hill, Barbados.
  • Hveem K; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Nielsen JB; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
  • Willer CJ; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Zwart JA; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Strand LB; Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Frayling TM; Department of Mathematics, Aston University, Birmingham, UK.
  • Ray D; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Lawlor DA; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Rutter MK; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Weedon MN; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Saxena R; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Nat Commun ; 10(1): 3503, 2019 08 13.
Article em En | MEDLINE | ID: mdl-31409809
Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sono / Loci Gênicos / Sonolência Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sono / Loci Gênicos / Sonolência Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article