Discovery of novel cage-like heterocyclic hybrids as anti-inflammatory agents through the inhibition of nitrite, PGE2 and TNF-α.
Bioorg Chem
; 91: 103180, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31416031
ABSTRACT
Novel cage-like indolizine-acenaphthene-pyridinone heterocyclic hybrids were synthesized in good yields through [bmim]Br mediated tandem 1,3-dipolar cycloaddition-annulation sequence. The anti-inflammatory activity of these hybrids was performed using carrageenan-induced hind paw oedema, croton oil-induced ear oedema and cotton pellet-induced granuloma models. Four of these cage-like heterocyclic hybrids viz. 4b, 4d, 4e and 4j showed substantial anti-inflammatory activities against acute and chronic inflammatory models and also showed significant inhibition of PGE2, TNF-α, and nitrite levels in carrageenan-induced hind paw oedema.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dinoprostona
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Fator de Necrose Tumoral alfa
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Edema
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Descoberta de Drogas
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Granuloma
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Compostos Heterocíclicos
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Anti-Inflamatórios
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Nitritos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article