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A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP ß-CTFs, Not Aß.
Kwart, Dylan; Gregg, Andrew; Scheckel, Claudia; Murphy, Elisabeth A; Paquet, Dominik; Duffield, Michael; Fak, John; Olsen, Olav; Darnell, Robert B; Tessier-Lavigne, Marc.
Afiliação
  • Kwart D; Laboratory of Brain Development and Repair, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
  • Gregg A; Laboratory of Brain Development and Repair, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
  • Scheckel C; Institute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.
  • Murphy EA; Laboratory of Neuro-oncology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
  • Paquet D; Laboratory of Brain Development and Repair, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.
  • Duffield M; Laboratory of Brain Development and Repair, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
  • Fak J; Laboratory of Neuro-oncology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
  • Olsen O; Laboratory of Brain Development and Repair, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
  • Darnell RB; Laboratory of Neuro-oncology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
  • Tessier-Lavigne M; Laboratory of Brain Development and Repair, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: tessier3@stanford.edu.
Neuron ; 104(2): 256-270.e5, 2019 10 23.
Article em En | MEDLINE | ID: mdl-31416668
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Endossomos / Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Endocitose / Presenilina-1 / Doença de Alzheimer / Neurônios Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Endossomos / Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Endocitose / Presenilina-1 / Doença de Alzheimer / Neurônios Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article