Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation.

Abdelaziz, Mohammed O; Ossmann, Sophia; Kaufmann, Andreas M; Leitner, Judith; Steinberger, Peter; Willimsky, Gerald; Raftery, Martin J; Schönrich, Günther

Abdelaziz, Mohammed O; Ossmann, Sophia; Kaufmann, Andreas M; Leitner, Judith; Steinberger, Peter; Willimsky, Gerald; Raftery, Martin J; Schönrich, Günther.

Afiliação

Abdelaziz MO; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Ossmann S; Clinic for Gynecology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Kaufmann AM; Clinic for Gynecology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Leitner J; Division of Immune Receptors and T Cell Activation, Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Steinberger P; Division of Immune Receptors and T Cell Activation, Institute of Immunology, Medical University of Vienna, Vienna, Austria.
Willimsky G; Institute of Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Raftery MJ; German Cancer Research Center, Heidelberg, Germany.
Schönrich G; German Cancer Consortium, Partner Site Berlin, Berlin, Germany.

Front Immunol ; 10: 1776, 2019.

Article em En | MEDLINE | ID: mdl-31417555

Assuntos

Apresentação de Antígeno; Antígenos de Neoplasias; Vacinas Anticâncer; Citomegalovirus; Glioblastoma; Antígenos de Histocompatibilidade Classe I/imunologia; Antígenos de Neoplasias/genética; Antígenos de Neoplasias/imunologia; Linfócitos T CD8-Positivos/imunologia; Vacinas Anticâncer/genética; Vacinas Anticâncer/imunologia; Linhagem Celular Tumoral; Citomegalovirus/genética; Citomegalovirus/imunologia; Glioblastoma/genética; Glioblastoma/imunologia; Papillomavirus Humano 16/genética; Papillomavirus Humano 16/imunologia; Humanos; Imunidade Celular; Proteínas Oncogênicas Virais/genética; Proteínas Oncogênicas Virais/imunologia; Proteínas E7 de Papillomavirus/genética; Proteínas E7 de Papillomavirus/imunologia; Proteínas Repressoras/genética; Proteínas Repressoras/imunologia

Palavras-chave

cancer immunotherapy; glioblastoma; human cytomegalovirus; therapeutic cancer vaccine; viral immune evasion

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe I / Apresentação de Antígeno / Glioblastoma / Vacinas Anticâncer / Citomegalovirus / Antígenos de Neoplasias Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google