Structural analysis of the transferrin receptor multifaceted ligand(s) interface.
Biophys Chem
; 254: 106242, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31419721
ABSTRACT
The transferrin receptor 1 (TfR1) is one of the key regulators of iron homeostasis for most higher organisms. It mediates cellular iron import through a constitutive clathrin-dependent endocytosis mechanism and by recruiting iron- regulator proteins as transferrin, Hereditary Hemochromatosis factor (HFE) and serum ferritin in response to cellular demand. The receptor is also opportunistically exploited by several viruses and the malaria parasite as a preferential door for cell invasion. In this review, we analyze the structural information available for TfR1 and all its functional complexes to figure out how structural signals in a single receptor can guide the recognition of multiple ligands and how the conservation of key residues in TfR1 might have a role in iron uptake and cell infection.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores da Transferrina
/
Ligantes
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article