Recent Highlights: Onco Viral Exploitation of the SUMO System.
Curr Issues Mol Biol
; 35: 1-16, 2020.
Article
em En
| MEDLINE
| ID: mdl-31422930
ABSTRACT
Small ubiquitin-like modifier (SUMO)ylation is a crucial post-translational modification that controls functions of a wide collection of proteins and biological processes. Hence, given its pleiotropic role, viruses have developed many approaches to usurp SUMO conjugation to exploit the cellular host environment for their own benefit. Consistently, cancer cells also frequently impact on SUMO to force cellular transformation, underlining the importance of SUMO in health and diseases. Therefore, after a brief introduction to the multistep SUMOylation pathway, in this review we will focus our attention on several examples of strategies adopted by oncogenic viruses to hijack SUMOylation in order to promote infection, persistence and malignant transformation of host cells.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retroviridae
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Proteínas Modificadoras Pequenas Relacionadas à Ubiquitina
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Sumoilação
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article