Prospects for Diminishing the Impact of Nonamyloid Small-Vessel Diseases of the Brain.
Annu Rev Pharmacol Toxicol
; 60: 437-456, 2020 01 06.
Article
em En
| MEDLINE
| ID: mdl-31425001
ABSTRACT
Small-vessel diseases (SVDs) of the brain are involved in about one-fourth of ischemic strokes and a vast majority of intracerebral hemorrhages and are responsible for nearly half of dementia cases in the elderly. SVDs are a heavy burden for society, a burden that is expected to increase further in the absence of significant therapeutic advances, given the aging population. Here, we provide a critical appraisal of currently available therapeutic approaches for nonamyloid sporadic SVDs that are largely based on targeting modifiable risk factors. We review what is known about the pathogenic mechanisms of vascular risk factor-related SVDs and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most frequent hereditary SVD, and elaborate on two mechanism-based therapeutic approaches worth exploring in sporadic SVD and CADASIL. We conclude by discussing opportunities and challenges that need to be tackled if efforts to achieve significant therapeutic advances for these diseases are to be successful.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Encefalopatias
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Aged
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Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article