ß-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: Possible relevance to male idiopathic infertility.
Mol Cell Endocrinol
; 498: 110545, 2019 12 01.
Article
em En
| MEDLINE
| ID: mdl-31425733
ABSTRACT
Catecholaminergic neuronal elements (CNE) and macrophages (MACs) are increased in testes of patients with idiopathic infertility. Now, we describe an anatomical proximity between CNE and MACs, expression of specific α- and ß-adrenergic receptors (ADRs) subtypes in MACs, and a positive correlation between the number of MACs and cyclooxygenase (COX2) expression - key enzyme in prostaglandin (PG) synthesis and an inflammatory marker - in testes of infertile men. To examine a potential effect of adrenergic input on COX2 expression, we used two additional experimental models non-testicular human MACs (THP1 cell line) and non-human testicular MACs purified from adult Syrian hamsters. We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through ß1-and ß2-ADRs. Our results demonstrate the existence of a yet unknown link between CNE and MACs in the human testis that could trigger inflammation and tissue homeostatic dysregulation associated with pathogenesis or maintenance of infertility states.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testículo
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Testosterona
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Prostaglandinas
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Receptores Adrenérgicos beta
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Ciclo-Oxigenase 2
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Infertilidade Masculina
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Macrófagos
Limite:
Adult
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Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article