Scopularides Revisited: Molecular Networking Guided Exploration of Lipodepsipeptides in Australian Marine Fish Gastrointestinal Tract-Derived Fungi.
Mar Drugs
; 17(8)2019 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-31426405
ABSTRACT
Chemical analysis of a cultivation of an Australian Mugil mullet gastrointestinal tract (GIT) derived fungus, Scopulariopsis sp. CMB-F458, yielded the known lipodepsipeptides scopularides A (1) and B (2). A comparative global natural product social (GNPS) molecular networking analysis of ×63 co-isolated fungi, detected two additional fungi producing new scopularides, with Beauveria sp. CMB-F585 yielding scopularides C-G (3-7) and Scopulariopsis sp. CMB-F115 yielding scopularide H (8). Structures inclusive of absolute configurations were assigned by detailed spectroscopic and C3 Marfey's analysis, together with X-ray analyses of 3 and 8, and biosynthetic considerations. Scopularides A-H (1-8) did not exhibit significant growth inhibitory activity against a selection of Gram positive (+ve) and negative (-ve) bacteria, a fungus, or a panel of three human carcinoma cell lines.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trato Gastrointestinal
/
Depsipeptídeos
/
Scopulariopsis
/
Peixes
Limite:
Animals
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Humans
País como assunto:
Oceania
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article