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LAG3: The Biological Processes That Motivate Targeting This Immune Checkpoint Molecule in Human Cancer.
Solinas, Cinzia; Migliori, Edoardo; De Silva, Pushpamali; Willard-Gallo, Karen.
Afiliação
  • Solinas C; Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, 1000 Brussels, Belgium.
  • Migliori E; Azienda Unità Sanitaria Locale Valle d'Aosta, Regional Hospital of Aosta, 11100 Aosta, Italy.
  • De Silva P; Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, 1000 Brussels, Belgium.
  • Willard-Gallo K; Columbia University Medical Center, Columbia Center for Translational Immunology, NY 10032, USA.
Cancers (Basel) ; 11(8)2019 Aug 20.
Article em En | MEDLINE | ID: mdl-31434339
ABSTRACT
The programmed cell death 1 (PD-1) pathway is an important regulator of immune responses in peripheral tissues, including abnormal situations such as the tumor microenvironment. This pathway is currently the principal target for immunotherapeutic compounds designed to block immune checkpoint pathways, with these drugs improving clinical outcomes in a number of solid and hematological tumors. Medical oncology is experiencing an immune revolution that has scientists and clinicians looking at alternative, non-redundant inhibitory pathways also involved in regulating immune responses in cancer. A variety of targets have emerged for combinatorial approaches in immune checkpoint blockade. The main purpose of this narrative review is to summarize the biological role of lymphocyte activation gene 3 (LAG3), an emerging targetable inhibitory immune checkpoint molecule. We briefly discuss its role in infection, autoimmune disease and cancer, with a more detailed analysis of current data on LAG3 expression in breast cancer. Current clinical trials testing soluble LAG3 immunoglobulin and LAG3 antagonists are also presented in this work.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article