Pyrimidine Nucleosides from Streptomyces sp. SSA28.
J Nat Prod
; 82(9): 2509-2516, 2019 09 27.
Article
em En
| MEDLINE
| ID: mdl-31436991
ABSTRACT
Eleven new pyrimidine nucleosides (1-11) and 12 known analogues (12-23) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new structures were elucidated by extensive NMR spectroscopic analysis and HRESIMS data. The absolute configurations of compound 1 were determined by X-ray diffraction. The configurations of 2-16 were investigated by ECD calculations. Compounds 11-16 showed cytotoxicity against HCT-116 human colon cancer cell lines with IC50 values from 0.39 ± 0.03 to 6.63 ± 0.47 µM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nucleosídeos de Pirimidina
/
Streptomyces
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article