17ß-Estradiol nongenomically induces vascular endothelial H<sub>2</sub>S release by promoting phosphorylation of cystathionine Î³-lyase.

Xu, Xingyan; Yan, Qing; Liu, Xiaoyun; Li, Ping; Li, Xiaosa; Chen, Yiwen; Simoncini, Tommaso; Liu, Junxiu; Zhu, Dongxing; Fu, Xiaodong

17ß-Estradiol nongenomically induces vascular endothelial H₂S release by promoting phosphorylation of cystathionine Î³-lyase.

Xu, Xingyan; Yan, Qing; Liu, Xiaoyun; Li, Ping; Li, Xiaosa; Chen, Yiwen; Simoncini, Tommaso; Liu, Junxiu; Zhu, Dongxing; Fu, Xiaodong.

Afiliação

Xu X; Department of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Yan Q; State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Liu X; Department of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Li P; State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Li X; Department of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Chen Y; State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Simoncini T; Department of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Liu J; State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Zhu D; Department of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Fu X; State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

J Biol Chem ; 294(43): 15577-15592, 2019 10 25.

Article em En | MEDLINE | ID: mdl-31439665

Assuntos

Cistationina gama-Liase/metabolismo; Estradiol/farmacologia; Células Endoteliais da Veia Umbilical Humana/metabolismo; Sulfeto de Hidrogênio/metabolismo; GMP Cíclico/metabolismo; Proteínas Quinases Dependentes de GMP Cíclico/metabolismo; Receptor alfa de Estrogênio/metabolismo; Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/metabolismo; Genoma Humano; Guanilato Ciclase/metabolismo; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Humanos; Modelos Biológicos; Fosforilação/efeitos dos fármacos; Ligação Proteica/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Vasodilatação/efeitos dos fármacos

Palavras-chave

17ß-estradiol; cell signaling; cyclic GMP (cGMP); cystathionine Î³-lyase; endothelial cell; estrogen; gene regulation; hydrogen sulfide; nongenomic regulation; protein kinase G (PKG); sulfur metabolism; vascular endothelial cells; vasodilation; vasorelaxation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cistationina gama-Liase / Estradiol / Células Endoteliais da Veia Umbilical Humana / Sulfeto de Hidrogênio Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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