Benign acute viral myositis in African migrants: A clinical, serological, and pathological study.
Muscle Nerve
; 60(5): 586-590, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31443116
BACKGROUND: Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series. METHODS: A detailed pathological and serological analysis was performed in five African migrants who developed an acute viral myositis complicated by rhabdomyolysis. RESULTS: Muscle biopsies clearly documented an inflammatory myopathy with histological features similar to polymyositis including CD8+ T cells surrounding and invading nonnecrotic muscle fibers, CD68+ macrophages and major histocompatibility complex class I antigen upregulation. In addition, positivity for myositis-specific antibodies (MSA), in particular anti-aminoacyl tRNA synthetases, was found in the serum of two patients. CONCLUSIONS: Our study demonstrated that T-cell mediated injury occurs in muscle of patients with acute viral myositis, and that MSA may be present in the serum of these patients.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Viroses
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Antígenos de Histocompatibilidade Classe I
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Linfócitos T CD8-Positivos
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Macrófagos
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Miosite
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
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Humans
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Male
País como assunto:
Africa
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Europa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article