Role of striatal &#916;FosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates.

Beck, Goichi; Singh, Arun; Zhang, Jie; Potts, Lisa F; Woo, Jong-Min; Park, Eun S; Mochizuki, Hideki; Mouradian, M Maral; Papa, Stella M

Role of striatal ΔFosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates.

Beck, Goichi; Singh, Arun; Zhang, Jie; Potts, Lisa F; Woo, Jong-Min; Park, Eun S; Mochizuki, Hideki; Mouradian, M Maral; Papa, Stella M.

Afiliação

Beck G; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329.
Singh A; Department of Neurology, Osaka University Graduate School of Medicine, 565-0871 Suita, Japan.
Zhang J; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329.
Potts LF; RWJMS Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854.
Woo JM; Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854.
Park ES; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329.
Mochizuki H; RWJMS Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854.
Mouradian MM; Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854.
Papa SM; RWJMS Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences, Piscataway, NJ 08854.

Proc Natl Acad Sci U S A ; 116(37): 18664-18672, 2019 09 10.

Article em En | MEDLINE | ID: mdl-31455727

Assuntos

Discinesia Induzida por Medicamentos/patologia; Levodopa/efeitos adversos; Neostriado/patologia; Doença de Parkinson/tratamento farmacológico; Proteínas Proto-Oncogênicas c-fos/metabolismo; Animais; Animais Geneticamente Modificados; Modelos Animais de Doenças; Feminino; Humanos; Macaca fascicularis; Masculino; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Proteínas Proto-Oncogênicas c-fos/genética; Regulação para Cima/efeitos dos fármacos

Palavras-chave

Parkinson's disease; l-Dopainduced dyskinesia; nonhuman primate models; striatal projection neurons; ΔFosB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Levodopa / Proteínas Proto-Oncogênicas c-fos / Neostriado / Discinesia Induzida por Medicamentos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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