The Role of Iron in Amyotrophic Lateral Sclerosis.
Adv Exp Med Biol
; 1173: 145-152, 2019.
Article
em En
| MEDLINE
| ID: mdl-31456209
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the motor cortex, brainstem, and spinal cord. The etiology and pathogenesis of this devastating disease remain largely unknown. Increasing evidence suggests that iron accumulation is involved in the onset and progression of ALS. In this review, we discuss the regulation of iron homoeostasis in the brain, the misregulation of iron homeostasis in ALS, and its possible roles in the mechanism of the disease. Finally, we summarize the recent progress and problems with respect to iron chelator therapies on ALS, aiming to propose a new therapeutic strategy to ameliorate the progression of the disease.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Esclerose Lateral Amiotrófica
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Ferro
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article