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Discovery of Arginine Ethyl Ester as Polyglutamine Aggregation Inhibitor: Conformational Transitioning of Huntingtin N-Terminus Augments Aggregation Suppression.
Singh, Virender; Patel, Kinjal A; Sharma, Raj Kumar; Patil, Pratik R; Joshi, Abhayraj S; Parihar, Rashmi; Athilingam, Thamarailingam; Sinha, Neeraj; Ganesh, Subramaniam; Sinha, Pradip; Roy, Ipsita; Thakur, Ashwani Kumar.
Afiliação
  • Singh V; Biological Sciences and Bioengineering , Indian Institute of Technology Kanpur , Kanpur , Uttar Pradesh 208016 , India.
  • Patel KA; Department of Physiology and Biophysics , Case Western Reserve University , Cleveland , Ohio 44106 , United States.
  • Sharma RK; Department of Biotechnology , National Institute of Pharmaceutical Education and Research , S.A.S. Nagar , Punjab 160062 , India.
  • Patil PR; Centre of Biomedical Research , SGPGIMS Campus, Raibarelly Road , Lucknow , Uttar Pradesh 226014 , India.
  • Joshi AS; Biological Sciences and Bioengineering , Indian Institute of Technology Kanpur , Kanpur , Uttar Pradesh 208016 , India.
  • Parihar R; Biological Sciences and Bioengineering , Indian Institute of Technology Kanpur , Kanpur , Uttar Pradesh 208016 , India.
  • Athilingam T; Biological Sciences and Bioengineering , Indian Institute of Technology Kanpur , Kanpur , Uttar Pradesh 208016 , India.
  • Sinha N; Biological Sciences and Bioengineering , Indian Institute of Technology Kanpur , Kanpur , Uttar Pradesh 208016 , India.
  • Ganesh S; Centre of Biomedical Research , SGPGIMS Campus, Raibarelly Road , Lucknow , Uttar Pradesh 226014 , India.
  • Sinha P; Biological Sciences and Bioengineering , Indian Institute of Technology Kanpur , Kanpur , Uttar Pradesh 208016 , India.
  • Roy I; Biological Sciences and Bioengineering , Indian Institute of Technology Kanpur , Kanpur , Uttar Pradesh 208016 , India.
  • Thakur AK; Department of Biotechnology , National Institute of Pharmaceutical Education and Research , S.A.S. Nagar , Punjab 160062 , India.
ACS Chem Neurosci ; 10(9): 3969-3985, 2019 09 18.
Article em En | MEDLINE | ID: mdl-31460743
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Arginina / Descoberta de Drogas / Agregados Proteicos / Proteína Huntingtina Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Arginina / Descoberta de Drogas / Agregados Proteicos / Proteína Huntingtina Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article