Enantioselective Alkylation of 2-Alkylpyridines Controlled by Organolithium Aggregation.
J Am Chem Soc
; 141(38): 15024-15028, 2019 09 25.
Article
em En
| MEDLINE
| ID: mdl-31460756
ABSTRACT
Direct enantioselective α-alkylation of 2-alkylpyridines provides access to chiral pyridines via an operationally simple protocol that obviates the need for prefunctionalization or preactivation of the substrate. The alkylation is accomplished using chiral lithium amides as noncovalent stereodirecting auxiliaries. Crystallographic and solution NMR studies provide insight into the structure of well-defined chiral aggregates in which a lithium amide reagent directs asymmetric alkylation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Piridinas
/
Lítio
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article