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Early life factors, gray matter brain volume and academic performance in overweight/obese children: The ActiveBrains project.
Solis-Urra, Patricio; Esteban-Cornejo, Irene; Cadenas-Sanchez, Cristina; Rodriguez-Ayllon, Maria; Mora-Gonzalez, Jose; Migueles, Jairo H; Labayen, Idoia; Verdejo-Román, Juan; Kramer, Arthur F; Erickson, Kirk I; Hillman, Charles H; Catena, Andrés; Ortega, Francisco B.
Afiliação
  • Solis-Urra P; PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Spain; IRyS Research Group, School of Physical Education, Pontificia
  • Esteban-Cornejo I; PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Spain; Department of Psychology, Northeastern University, Boston, MA
  • Cadenas-Sanchez C; PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Spain.
  • Rodriguez-Ayllon M; PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Spain.
  • Mora-Gonzalez J; PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Spain.
  • Migueles JH; PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Spain.
  • Labayen I; Institute for Innovation & Sustainable Development in Food Chain (IS-FOOD), Public University of Navarra, Pamplona, Spain.
  • Verdejo-Román J; Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for Biomedical Technology (CTB), Pozuelo de Alarcón, Spain.
  • Kramer AF; Department of Psychology, Northeastern University, Boston, MA, USA; Beckman Institute, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
  • Erickson KI; Department of Psychology, University of Pittsburgh, 3601 Sennott Square, Pittsburgh, PA, USA.
  • Hillman CH; Department of Psychology, Northeastern University, Boston, MA, USA; Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, USA.
  • Catena A; Department of Experimental Psychology, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, Granada, Spain.
  • Ortega FB; PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Spain.
Neuroimage ; 202: 116130, 2019 11 15.
Article em En | MEDLINE | ID: mdl-31465844
Early life factors may influence brain and academic outcomes later in life, especially during childhood. Here we investigate the associations of early life factors (i.e., birth weight, birth length, and breastfeeding) with gray matter volume, adjusted for body mass index and cardiorespiratory fitness, and ii) we test whether early-life factor-related differences in gray matter volume are associated with academic performance in overweight/obese children. 96 children with overweight/obesity aged 8-11 years participated. Birth weight, birth length and gestational age were collected from birth records, and breastfeeding practices were asked to parents. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Academic performance was assessed with the Bateria III Woodcock-Muñoz Tests of Achievement. Whole-brain voxel-wise multiple regressions were used to test the associations of each early life factor with gray matter volume. Higher birth weight and birth length were associated with greater gray matter volume in 9 brain regions including the middle frontal gyrus, rectal gyrus, thalamus, putamen, middle temporal gyrus, lingual gyrus, middle occipital gyrus, calcarine cortex and cerebellum bilaterally (ß ranging from 0.361 to 0.539, t ranging from 3.46 to 5.62 and cluster size from 82 to 4478 voxels; p < 0.001); and greater duration of any breastfeeding was associated with greater gray matter volume in 3 regions including the bilateral inferior frontal gyrus and rolandic operculum (ß ranging from 0.359 to 0.408, t ranging from 4.01 to 4.32 and cluster size from 64 to 171 voxels; p < 0.001). No associations were found for duration of exclusive breastfeeding. Additionally, none of the gray matter regions that were associated with the early life factors were associated with academic performance (all p > 0.05). Our results demonstrate that birth weight, birth length, and breastfeeding are predictive of gray matter volume of numerous brain structures that are involved in higher order cognition and emotion regulation, but how these results relate to measures of academic achievement remain a matter of speculation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Estatura / Aleitamento Materno / Sobrepeso / Substância Cinzenta / Desempenho Acadêmico Tipo de estudo: Prognostic_studies Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Estatura / Aleitamento Materno / Sobrepeso / Substância Cinzenta / Desempenho Acadêmico Tipo de estudo: Prognostic_studies Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article